PLoS ONE 8(10):Įditor: C Andrew Boswell, Genentech, United States of America (2013) Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET. These results are the first report of direct PET imaging of LAT1 and demonstrate the potential of immunoPET agents for imaging specific amino acid transporters.Ĭitation: Ikotun OF, Marquez BV, Huang C, Masuko K, Daiji M, Masuko T, et al.
Blocking studies with unlabeled anti-LAT1 antibody demonstrated a 55% reduction of DFO-Ab2 accumulation in the tumor at 7 days. In contrast, the peak tumor uptake of the radiolabeled amino acid FET was 4.4 ± 0.5 %ID/g at 30 min after injection with a tumor to muscle ratio of 1.4 to 1. Biodistribution studies demonstrated tumor uptake of 10.5 ± 1.8 percent injected dose per gram (%ID/g) at 7 days with a tumor to muscle ratio of 13 to 1. PET imaging studies showed high tumor uptake, with optimal tumor-to-non target contrast achieved at 7 days post administration. This tracer demonstrated specificity for LAT1 in vitro and in vivo with excellent tumor imaging properties in mice with xenograft tumors. Here, we describe the development and biological evaluation of a novel zirconium-89 labeled antibody, DFO-Ab2, targeting the extracellular domain of LAT1 in a preclinical model of colorectal cancer. Radiolabeled amino acids such as O-(2-fluoroethyl)-L-tyrosine (FET) that are transport substrates for system L amino acid transporters including LAT1 have met limited success for oncologic imaging outside of the brain, and thus new strategies are needed for imaging LAT1 in systemic cancers. Momentus cited additional time needed for regulatory approval as the cause of the change.The L-type amino acid transporter-1 (LAT1, SLC7A5) is upregulated in a wide range of human cancers, positively correlated with the biological aggressiveness of tumors, and a promising target for both imaging and therapy. Those 10 satellites were added after Momentus took its first Vigoride mission off the Transporter-1 launch earlier this month. Notably, the 10 Starlink satellites aboard this mission will be the first in the constellation to deploy to a polar orbit, as the company continues to expand public access to its satellite internet network.
SpaceX's customers on board Transporter-1 include: Planet Labs, Exolaunch, D-Orbit, Kepler Communications, Spaceflight Inc, Nanoracks, NASA and Capella Space, as well as iQPS, Loft Orbital, Spire Global, ICEYE, HawkEye 360, Astrocast, and the University of South Florida Institute of Applied Engineering. "A fairly reliable 'bus route' is available," Smith said of SpaceX, "whereas I suppose one might compare companies like Rocket Lab and Virgin Orbit as on-call taxies that get your satellite where you want it ASAP."Įlon Musk's company launched 133 satellites for a broad variety of government and private customers, as well as 10 of its own Starlink satellites. The SpaceX service is not quite on demand, Smith said, but companies can pay a premium to launch according to their schedule, rather than the schedule of the primary customer.
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